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1

Investigation of Practical Routes for the Kilogram-Scale Production of cis -3-Methylamino-4-methylpiperidines

Cai, Weiling, Colony, James L., Frost, Heather, Hudspeth, James P., Kendall, Peter M., Krishnan, Ashwin M., Makowski, Teresa, Mazur, Duane J., Phillips, James, Ripin, David H. Brown, Ruggeri, Sally Gu

Journal:

Organic Process Research & Development

Year:

2005

Language:

english

File:

PDF, 149 KB

english, 2005

2

Process Improvements for the Manufacture of Tenofovir Disoproxil Fumarate at Commercial Scale

Brown Ripin, David H., Teager, David S., Fortunak, Joseph, Basha, Shaik Mahaboob, Bivins, Nylea, Boddy, Christopher N., Byrn, Stephen, Catlin, Kelly K., Houghton, Stephen R., Jagadeesh, S. Tirumala

Journal:

Organic Process Research & Development

Year:

2010

Language:

english

File:

PDF, 646 KB

english, 2010

3

Large-Scale Oxidations in the Pharmaceutical Industry†

Caron, Stéphane, Dugger, Robert W., Ruggeri, Sally Gut, Ragan, John A., Ripin, David H. Brown

Journal:

Chemical Reviews

Year:

2006

Language:

english

File:

PDF, 1.67 MB

english, 2006

4

Development of a Scaleable Route for the Production of cis - N -Benzyl-3-methylamino-4-methylpiperidine

Ripin, David H. Brown, Abele, Stefan, Cai, Weiling, Blumenkopf, Todd, Casavant, Jeffrey M., Doty, Jonathan L., Flanagan, Mark, Koecher, Christian, Laue, Klaus W., McCarthy, Keith, Meltz, Cliff, Munchh

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 137 KB

english, 2003

5

Thermal stability investigation of pyridine substituted tosyl oximes

David J. am Ende, David H. Brown Ripin, Neil P. Weston

Journal:

Thermochimica Acta

Year:

2004

Language:

english

File:

PDF, 223 KB

english, 2004

6

Process Enabling and the Scale-Up of 6β-Hydroxymethylsulbactam and Its Esters

Norris, Timothy, Ripin, David H. Brown, Ahlijanian, Paul, Andresen, Brian M., Barrila, Mark T., Colon-Cruz, Roberto, Couturier, Michel, Hawkins, Joel M., Loubkina, Ioulia V., Rutherford, Jennifer, Sti

Journal:

Organic Process Research & Development

Year:

2005

Language:

english

File:

PDF, 301 KB

english, 2005

7

Execution of a Performic Acid Oxidation on Multikilogram Scale

Ripin, David H. Brown, Weisenburger, Gerald A., am Ende, David J., Bill, David R., Clifford, Pamela J., Meltz, Clifford N., Phillips, James E.

Journal:

Organic Process Research & Development

Year:

2007

Language:

english

File:

PDF, 141 KB

english, 2007

8

Neue Anwendung von N-Acylimiden als chirale Auxiliare für Aldol- und Diels-Alder-Reaktionen - enantioselektive Synthese von α-Himachalen

Prof. David A. Evans, David H. Brown Ripin, Jeffrey S. Johnson, Eileen A. Shaughnessy

Journal:

Angewandte Chemie

Year:

1997

File:

PDF, 353 KB

1997

9

A New Strategy for Extending N-Acyl Imides as Chiral Auxiliaries for Aldol and Diels–Alder Reactions: Application to an Enantioselective Synthesis of α-Himachalene

Prof. David A. Evans, David H. Brown Ripin, Jeffrey S. Johnson, Eileen A. Shaughnessy

Journal:

Angewandte Chemie International Edition

Year:

1997

Language:

english

File:

PDF, 384 KB

english, 1997

10

ChemInform Abstract: A Safe, Scalable Method for the Oxidation of Carbon—Boron Bonds with Oxone®.

David H. Brown Ripin, Weiling Cai, Steven J. Brenek

Journal:

Year:

2000

File:

PDF, 33 KB

2000

11

ChemInform Abstract: A Practical Synthesis of Pyridylboranes via Magnesium—Halogen Exchange.

Weiling Cai, David H. Brown Ripin

Journal:

Year:

2002

File:

PDF, 27 KB

2002

12

2-Methyltetrahydrofuran as an Alternative to Dichloromethane in 2-Phase Reactions.

David H. Brown Ripin, Michael Vetelino

Journal:

Year:

2004

File:

PDF, 106 KB

2004

13

Rapid, mild method for phosphonate diester hydrolysis: development of a one-pot synthesis of tenofovir disoproxil fumarate from tenofovir diethyl ester

Stephen R. Houghton, Jack Melton, Joseph Fortunak, David H. Brown Ripin, Christopher N. Boddy

Journal:

Year:

2010

Language:

english

File:

PDF, 851 KB

english, 2010

14

A safe, scaleable method for the oxidation of carbon–boron bonds with oxone®

David H.Brown Ripin, Weiling Cai, Steven J Brenek

Journal:

Tetrahedron Letters

Year:

2000

Language:

english

File:

PDF, 88 KB

english, 2000

15

Optimising the manufacture, formulation, and dose of antiretroviral drugs for more cost-efficient delivery in resource-limited settings: a consensus statement

Keith W Crawford, David H Brown Ripin, Andrew D Levin, Jennifer R Campbell, Charles Flexner

Journal:

The Lancet Infectious Diseases

Year:

2012

Language:

english

File:

PDF, 210 KB

english, 2012

16

Evaluation of Kilogram-Scale Sonagashira, Suzuki, and Heck Coupling Routes to Oncology Candidate CP-724,714

Ripin, David H. Brown, Bourassa, Dennis E., Brandt, Thomas, Castaldi, Michael J., Frost, Heather N., Hawkins, Joel, Johnson, Phillip J., Massett, Stephen S., Neumann, Karin, Phillips, James, Raggon, J

Journal:

Organic Process Research & Development

Year:

2005

Language:

english

File:

PDF, 148 KB

english, 2005

17

Safety vs Efficiency in the Development of a High-Energy Compound

Ruggeri, Sally Gut, Bill, David R., Bourassa, Dennis E., Castaldi, Michael J., Houck, Tim L., Ripin, David H. Brown, Wei, Lulin, Weston, Neil

Journal:

Organic Process Research & Development

Year:

2003

Language:

english

File:

PDF, 72 KB

english, 2003

18

Survey of GMP Bulk Reactions Run in a Research Facility between 1985 and 2002

Dugger, Robert W., Ragan, John A., Ripin, David H. Brown

Journal:

Organic Process Research & Development

Year:

2005

Language:

english

File:

PDF, 60 KB

english, 2005

19

Route Development and Bulk Synthesis of CP-865,569

Belecki, Katherine, Berliner, Martin, Bibart, Richard Todd, Meltz, Cliff, Ng, Karl, Phillips, James, Ripin, David H. Brown, Vetelino, Michael

Journal:

Organic Process Research & Development

Year:

2007

Language:

english

File:

PDF, 97 KB

english, 2007

20

Treatment optimization

Flexner, Charles, Plumley, Ben, Brown Ripin, David H.

Journal:

Current Opinion in HIV and AIDS

Year:

2013

Language:

english

File:

PDF, 175 KB

english, 2013

21

2-Methyltetrahydrofuran as an Alternative to Dichloromethane in 2-Phase Reactions

Brown Ripin, David H., Vetelino, Michael

Journal:

Year:

2003

Language:

english

File:

PDF, 16 KB

english, 2003

22

A Practical Synthesis of Pyridylboranes via Magnesium-Halogen Exchange

Cai, Weiling, Brown Ripin, David H.

Journal:

Year:

2002

Language:

english

File:

PDF, 31 KB

english, 2002

23

Optimizing Antiretroviral Product Selection: A Sample Approach to Improving Patient Outcomes, Saving Money, and Scaling-up Health Services in Developing Countries

Amole, Carolyn D, Brisebois, Catherine, Essajee, Shaffiq, Koehler, Erin, Levin, Andrew D, Moore, Meredith C, Brown Ripin, David H, Sickler, Joanna J, Singh, Inder R

Journal:

JAIDS Journal of Acquired Immune Deficiency Syndromes

Year:

2011

Language:

english

File:

PDF, 171 KB

english, 2011